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Symbol Name ID |
Foxo1
forkhead box O1 MGI:1890077 |
| Darker colors indicate more annotations |
| Mouse Phenotypes | decreased thymocyte apoptosis |
decreased T cell proliferation |
increased T cell proliferation |
increased susceptibility to induced colitis |
enlarged spleen |
decreased double-positive T cell number |
increased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased regulatory T cell number |
decreased T cell number |
increased T cell number |
increased single-positive T cell number |
abnormal single-positive T cell number |
small spleen |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal T cell activation |
abnormal regulatory T cell physiology |
decreased circulating tumor necrosis factor level |
enlarged lymph nodes |
small lymphoid organs |
increased interferon-gamma secretion |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
abnormal inflammatory response |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Foxo1tm2.1Dac/Foxo1tm2.1Dac | ||||||||||||||||||||||||||||
| Foxo1tm1.1Stlp/Foxo1tm1.1Stlp Tg(Lck-cre)1Cwi/0 (conditional) |
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| Foxo1tm1Flv/Foxo1tm1Flv Tg(Cd4-cre)1Cwi/? (conditional) |
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| Foxo1tm1Flv/Foxo1tm1Flv Ndor1Tg(UBC-cre/ERT2)1Ejb/0 (conditional) |
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| Foxo1tm1Flv/Foxo1tm1Flv Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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